Govaresh. 2014; 18 (4): 257-260
in English
| IMEMR
| ID: emr-142009
ABSTRACT
Rhabdomyolysis is a serious clinical condition resulting from release of toxic intracellular materials into the systemic circulation. Multiple factors have been demonstrated to be responsible for this syndrome. However, currently medications and alcohol are considered to be the primary causative agents. To the best of our knowledge there are few reported cases of rhabdomyolysis following prescription of peginterferon alfa-2b in patients with chronic hepatitis. Here, we have reported the case of a 46-year-old male with hepatitis C virus [HCV] infection who suffered an acute onset of generalized myalgia and weakness, with elevated serum creatine phosphokinase [CPK] and lactate dehydrogenase [LDH] levels six months after administration of peginterferon alfa-2b. Considering the clinical picture and laboratory findings, we diagnosed the patient with rhabdomyolysis. Peginterferon alfa-2b and ribavirin were discontinued and intensive intravenous hydration commenced. Within ten days the patient improved significantly after which he was discharged in an appropriate physical condition.
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Polyethylene Glycols
/
Recombinant Proteins
/
Interferon-alpha
/
Hepatitis C, Chronic
Type of study:
Case report
Limits:
Humans
/
Male
Language:
English
Journal:
Govaresh
Year:
2014
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