Lipid profile in females of reproductive age group using injectable contraceptives [progestogen-only]

ABSTRACT

To determine and compare the values of lipid profile in married fertile females of reproductive age group using injectable contraceptives. Comparative cross sectional study. This study was carried out in the Department of Biochemistry, Postgraduate Medical Institute, Lahore and Lahore General Hospital, Lahore from July 2010 to Dec 2010. A total of 250 married fertile women in their reproductive age were selected. They were divided in two groups Group 1 [controls] and Group 2 [injectable contraceptive users]. Levels of s erum total cholesterol, serum triglycerides, high density lipoprotein-cholesterol were measured using standard kits. Low density lipoprotein-cholesterol was calculated with Fried Wald equation. Results were analyzed by using student's t test. Informed consent was taken from each patient and control subject for this study. Injectable contraceptives cause significant decrease in HDL-C and significant increase in serum triglycerides and LDL-C. It is suggested that Lipid profile should be estimated before starting every course [the course may be 3-6months] of injectable contraceptives to the subjects: