Synthesis and cytotoxic activity of some derivatives of alkyl piperidine
Pakistan Journal of Pharmaceutical Sciences. 2013; 26 (3): 517-523
in English
| IMEMR
| ID: emr-142612
ABSTRACT
Synthesis of novel phenacyl derivatives of alkyl piperidine as cytotoxic agents via simple and single step reaction procedure is going to be reported here. Twelve new compounds were successfully synthesized in moderate yield and in solid form. Their synthesis was confirmed by TLC, melting point, CHN analysis and through different spectral studies such as UV, IR, Mass and proton NMR. The advantages of this synthetic route are simple operation, mild reaction conditions and good yields. These newly synthesized derivatives were extensively explored for their cytotoxicity by brine shrimp lethality assay
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Piperidines
/
Artemia
/
Magnetic Resonance Spectroscopy
/
Toxicity Tests
/
Alkylation
Language:
English
Journal:
Pak. J. Pharm. Sci.
Year:
2013
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