Validating a stability indicating HPLC method for kinetic study of cetirizine degradation in acidic and oxidative conditions
IJPR-Iranian Journal of Pharmaceutical Research. 2013; 12 (2): 287-294
in English
| IMEMR
| ID: emr-142648
ABSTRACT
A stability indicating High-Performance Liquid Chromatography [HPLC] method was validated and used to study the degradation of cetirizine dihydrochloride in acidic and oxidative conditions. The separation was carried out on a Symmetry C18 column and a mixture of 50 mM KH[2]PO[4] and acetonitrile [6040 v/v, pH = 3.5] was used as the mobile phase. The method was linear over the range of 1-20 micro g/mL of cetirizine dihydrochloride [r[2] > 0.999] and the within-day and between-day precision values were less than 1.5%. The results showed that cetirizine dihydrochloride was unstable in 2 M HCl and 0.5% H[2]O[2]. The kinetics of the acidic degradation showed a pseudo-first-order reaction in the temperature range of 70-90[degree sign]C. In addition, the kinetics of hydrogen peroxide mediated degradation was pseudo-first-order in the temperature range of 50-80[degree sign]C
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Reproducibility of Results
/
Cetirizine
/
Drug Stability
Language:
English
Journal:
Iran. J. Pharm. Res.
Year:
2013
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