Anti-HIV-1 activities of extracts and phenolics from Smilax China l.

ABSTRACT

Four extracts [EtOH, CHCl[3], EtOAc, and BuOH] and five phenolics [dihydrokaempferol [1], resveratrol [2], kaempferol-7-O-beta-D-glucoside [3], dihydrokaempferol-3-O-alpha-L-rhamnoside [4], oxyresveratrol [5]] from Smilax china L. was evaluated for anti-HIV-1 activities and cytotoxicity activities in vitro. All these extracts and phenolics showed lower or no cytotoxicity at a concentration ranged from 0.8 microg/mL to 100 microg/mL, but some showed potential anti-HIV-1 activities, that is, BuOH extract and compound 2 showed higher anti-HIV-1 activities than other extracts and compounds in the tested concentrations. EtOAc extract and compound 1 and 3 showed moderate anti-HIV-1 activities at a concentration higher than 4 microg/mL. In the end, the structure-activity relationship of four extracts and five phenolics was discussed.