Anti hyperalgesic potentials of Laggera aurita in Swiss Albino mice
Pakistan Journal of Pharmaceutical Sciences. 2014; 27 (1): 169-172
in English
| IMEMR
| ID: emr-142996
ABSTRACT
The ethnomedical uses of Laggera aurita [LA], including its anti-nociceptive properties have been documented in literature. This study evaluated the anti-hyperalgesic effects of the methanolic extract of LA [MELA] using chemically and mechanically induced hyperalgesia models. Acute toxicity and preliminary phytochemical screening were also conducted. The intraperitoneal median lethal dose was found to be 3807.88 mg/kg, while saponins, tannins and carbohydrates were found to be present in the plant material. MELA exhibited significant analgesic activity in the acetic acid induced writhing and Randall-Siletto tests. The 400 mg/kg dose of MELA exhibited a significant [p<0.001] analgesic activity which offered 19.75% inhibition above piroxicam in the acetic acid test. At 200 and 400 mg/kg MELA demonstrated comparative analgesia with pentazocine in the Randall-Siletto test. The study shows that MELA possesses anti-nociceptive principles and the presence of saponins, tannins and carbohydrates which have been previously associated with anti-hyperalgesia may be responsible for the pharmacological actions, thus authenticating the ethnomedical rationale for its anti-nociceptive uses.
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Plant Extracts
/
Hyperalgesia
/
Analgesics
/
Phytotherapy
/
Mice
Limits:
Animals
Language:
English
Journal:
Pak. J. Pharm. Sci.
Year:
2014
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