Correlation between hepatitis B surface antigen titers and HBV DNA levels
Saudi Journal of Gastroenterology [The]. 2013; 19 (6): 252-257
in English
| IMEMR
| ID: emr-143005
ABSTRACT
To assess the correlation between serum HBsAg titers and hepatitis B virus [HBV] DNA levels in patients with hepatitis B envelop antigen-negative [HBeAg -ve] HBV genotype-D [HBV/D] infection. A total of 106 treatment- nave, HBeAg -ve HBV/D patients were included; 78 in the inactive carrier [IC] state and 28 in the active hepatitis [AH] stage. HBV DNA load and HBsAg titers were tested using TaqMan real-time polymerase chain reaction [PCR] and automated chemiluminescent microparticle immunoassay, respectively. The median [range] log10 HbsAg titer was significantly lower in the IC group compared with AH group, 3.09 [-1 to -4.4] versus 3.68 [-0.77 to 5.09] IU/mL, respectively; P < 0.001. The suggested cutoff value of HBsAg titer to differentiate between the two groups was 3.79 log10 IU/mL. In addition, there was a significant positive correlation between HBsAg and HBV DNA levels in the whole cohort, AH, and IC groups [r = 0.6, P < 0.0001; r = 0.591, P = 0.001; and r = 0.243, P = 0.032, respectively]. Serum HBsAg titers may correlate with HBV DNA in treatment-nave HBeAg -ve HBV/D patients, and supports the use of HBsAg levels in clinical practice as a predictor of serum HBV DNA levels.
Search on Google
Index:
IMEMR (Eastern Mediterranean)
Main subject:
DNA, Viral
/
Viral Envelope Proteins
/
Hepatitis B virus
/
Genome, Viral
/
Hepatitis B, Chronic
/
Hepatitis B Surface Antigens
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Saudi J. Gastroenterol.
Year:
2013
Similar
MEDLINE
...
LILACS
LIS