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JAK2 V617 mutation triggers erythropoiesis and patients present with good hemoglobin level in idiopathic myelofibrosis [IMF]
Esculapio. 2013; 9 (1): 15-16
in English | IMEMR | ID: emr-143126
ABSTRACT
To document the impact of JAK2 mutation on hemoglobin [Hb] level in patients with IMF. Thirty five patients were studied out of which 19 were JAK2 positive and 16 were JAK2 negative. Sample collection technique was purposive non-probability sampling. Variations were observed among the studied JAK2 positive and JAK2 negative patients regarding hemoglobin level. In JAK2 positive and negative patients mean hemoglobin level was 10.6g/dl and 8.6g/dl respectively [p=0.29]. Due to the better hemoglobin level, patients with JAK2 mutation have less transfusion requirements and are partially protected against severe anemias compared to patients with no mutation.
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Index: IMEMR (Eastern Mediterranean) Main subject: Blood Transfusion / Hemoglobins / Primary Myelofibrosis / Mutation / Myeloproliferative Disorders Language: English Journal: Esculapio Year: 2013

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Index: IMEMR (Eastern Mediterranean) Main subject: Blood Transfusion / Hemoglobins / Primary Myelofibrosis / Mutation / Myeloproliferative Disorders Language: English Journal: Esculapio Year: 2013