Thrombotic thrombocytopaenic purpura in a patient presenting with sickle cell -hemoglobin S disease vaso-occlusive crises and acute chest syndrome

ABSTRACT

The association of sickle cell disease [SCA] vaso-occlusive crises and Thrombotic thrombocytopaenic purpura [TTP] has been rarely described. Here we report a case of sickle cell - haemoglobin S disease [HbSS] in which a patient presented with painful vaso-occlusive crises and acute chest syndrome and TTP which was a diagnostic challenge. We also conducted a Medline search to review reported cases previously