Hypoglycemic effect of ethanolic extract of Carum carvi L. seeds in normal and streptozotocin-induced diabetic rats
Journal of Medicinal Plants. 2010; 9 (35): 106-113
in English
| IMEMR
| ID: emr-143736
ABSTRACT
Herbal medicine has been used for many years by different cultures around the world for the treatment of diabetes. The hypoglycemic effect of caraway ethanolic extract [Carum carvi L.] was investigated in normal and streptozotocin-induced diabetic rats. Intraperitoneal administration of caraway ethanolic extract seeds [0.1, 0.2, 0.4 and 0.6 g/kg body wt.] on the level of serum glucose and insulin in normal and streptozotocin-induced diabetic rats were evaluated. Before administration and 1, 3 and 5 h after administrations of the ethanolic extract, blood samples were drawn from the retro-orbital sinus. Serum glucose and insulin levels were determined. The results showed that the caraway ethanolic extract seeds at doses 0.2, 0.4 and 0.6 g/kg body wt. significantly decreased serum glucose and insulin in diabetic rats in 3 and 5 h but not in healthy rats. It could be proofed that the traditional use of caraway as a hypoglycemic agent is justified and that extract from this plant show a dose-dependent hypoglycemic activity
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Plants, Medicinal
/
Plant Extracts
/
Rats, Wistar
/
Streptozocin
/
Diabetes Mellitus, Experimental
/
Hypoglycemic Agents
/
Phytotherapy
Limits:
Animals
Language:
English
Journal:
J. Med. Plants
Year:
2010
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