[Neuroprotective effect of aqueous extract of Berberis vulgaris L. in a model of parkinson's disease in rat]

ABSTRACT

Parkinson's disease is a neurodegenerative disease of dopaminergic neurons in substancia nigra. Superoxides formation is one of the main etiologies of the disease, and angiotensin converting enzyme inhibitors [ACEIs] are able to suppress superoxide formation. Berberis vulgaris is an ACE inhibitor and considered for this purpose. Male rats [n=32] were divided in 4 groups Sham, Neurotoxin [injection of 6-hydroxydopamine into left hemisphere SNC], Berberis vulgaris aqueous extract [10 mg/kg] and captopril. Berberis and captopril were injected i.p. 7 days before and 3 days after 6-hydroxydopamine injection. Muscle rigidity, apomorphine test, brain protein oxidation and lipid peroxidation as well as serum and brain ACE activity were assayed in all 4 groups. Rotation test with apomorphine in captopril and Berberis groups were significantly lower than neurotoxin group [p=0.002]. Lipid peroxidation in captopril was significantly lower than neurotoxin [p=0.013]. Captopril and Berberis both inhibited serum ACE activity respectively, but Berberis inhibited brain ACE too. Berberis vulgaris aqueous extract is an ACE inhibitor with anti-parkinsonism effect and should be studied more