[Applications of quantum dots in cell tracking]

ABSTRACT

Tracking cells after transplantation is always one the main concerns of researchers in the field of regenerative medicine. Finding a tracer with long stability and low cytotoxicity can be considered as a solution for this issue. Semiconductor nanocrystals, also called quantum dots [QDs], have unique photophysical properties which make them as suitable candidate in this setting. Broad-range excitation, size-tunable narrow emission spectrum, high brightness and their exceptional resistance against photobleaching are among characteristics which enable the researchers to use these nanoparticles in long-term, multi-target and high sensitive in vivo imaging of live animals. However, due to the toxic components found in QDs core caution must be exercised in their clinical usage. This review summarizes the role of QDs in cellular tracking and is concerned about their potential cytotoxicity