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Effect of sevoflurane combination with epidural anesthesia on myocardial injury in patients with coronary artery disease undergoing non-cardiac surgery
Saudi Medical Journal. 2011; 32 (10): 1009-1016
in English | IMEMR | ID: emr-144009
ABSTRACT
To determine the effect of sevoflurane combination with epidural anesthesia on myocardial injury in patients with coronary artery disease [CAD] undergoing non-cardiac surgery. The investigation was performed in TianJin NanKai Hospital, TianJin, China from November 2009 to March 2010. Eighty patients with CAD undergoing elective abdominal surgery were randomized into 4 groups group S1- combined sevoflurane general and epidural anesthesia; group S2 - standard sevoflurane general anesthesia; group P1 - combined propofol general and epidural anesthesia; and group P2 - standard propofol general anesthesia. Mean arterial pressure, central venous pressure, electrocardiogram, and bispectral index was monitored throughout the surgery. The serum levels of interleukin-6 [IL-6], interleukin-8 [IL-8], tumor necrosis factor-alpha TNF-alpha, cardiac troponin I [cTnI], and glycogen phosphorylase BB [GP-BB] was measured at different time points during surgery. The ST depression in group P1 and S2 was significantly higher than that in group S1 [p=0.000] and lower than that in group P2 [p=0.00]. The serum levels of IL-6, IL-8, TNF-alpha, cTnI, and GP-BB in group P1 and S2 were dramatically greater than that in group S1 [p=0.00], and lower than that in group P2 [p=0.00]. Sevoflurane in combination with continuous epidural anesthesia could protect against myocardial damage in patients with CAD, downregulation of IL-6, IL-8, and TNF-alpha might contribute to this protection
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Index: IMEMR (Eastern Mediterranean) Main subject: General Surgery / Coronary Artery Disease / Myocardial Reperfusion Injury / Anesthesia, Epidural Limits: Female / Humans / Male Language: English Journal: Saudi Med. J. Year: 2011

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Index: IMEMR (Eastern Mediterranean) Main subject: General Surgery / Coronary Artery Disease / Myocardial Reperfusion Injury / Anesthesia, Epidural Limits: Female / Humans / Male Language: English Journal: Saudi Med. J. Year: 2011