Effect of 12 weeks life-style activity modification on serum oxidized LDL-C in obese men

ABSTRACT

Exercise significantly prevents the progression of atherosclerosis and oxidized LDL-C [ox-LDL-C], facilitates monocyte-related atherogenesis. The effects of Lifestyle Activity Modification [LAM] training based on guidelines of the Centers for Disease Control [CDC] and the American College of Sports Medicine [ACSM] on serum oxidized LDL-C [ox-LDL-C] in obese people are not well known. We investigated the effect of LAM on serum ox-LDL-C in obese middle aged men. Sixteen healthy obese middle aged men [aged 42.06 +/- 6.01 years, mean +/- SD] were randomly assigned to the LAM [n=8] and the control [n=8] groups. Subjects in the LAM group walked 2 miles daily in 30 minutes 4 days weekly for 12 weeks on treadmills, according to the CDC and ACSM guidelines. Results showed that body weight, BMI, body fat mass, body fat percent, waist to hip ratio [WHR] and LDL-C decreased significantly after 12 weeks in the LAM group compared to the controls [P<0.05], and their maximum oxygen uptake was increased significantly compared to the controls after 12 weeks [P<0.05]. On the other hand, after 12 weeks of LAM training, no significant differences were observed in serum ox-LDL-C, total cholesterol [TC], triglycerides [TG] and HDL-C between the groups. Although twelve weeks of LAM improved body composition and cardio-respiratory fitness and decreased LDL-C levels in obese middle aged men, serum ox-LDL-C were not affected by this protocol in this group