Does inhibin-B help us to confidently refuse diagnostic testicular biopsy in azoospermia?
IJRM-Iranian Journal of Reproductive Medicine. 2012; 10 (3): 243-248
in English
| IMEMR
| ID: emr-144285
ABSTRACT
In the recent years, the use of laboratory blood factors such as FSH and inhibin-B for the assessment of spermatogenesis in different studies has increased; of course, the conflicting results have also been achieved. To investigate if the measurement of inhibin-B can help surgeon to reduce unnecessary diagnostic testicular biopsies in males with azoospermia. This cross-sectional study was done during July 2006 to September 2007 on 41 patients with azoospermia. FSH and inhibin-B were measured and bilateral open testicular biopsy was performed for all patients. Sperm was seen in 29% of biopsies that in 100% of these samples inhibin-B was more than 100 pg/mL and FSH was less than twice the normal [p=0.001]. Inhibin-B had significant correlation inversely with testicular fibrosis and Sertoli cell only syndrome [p=0.043 and p=0.011, respectively] and directly with incomplete spermatocytic maturation arrest and obstructive azoospermia [p=0.027 and p=0.013, respectively]. FSH was only correlated with obstructive azoospermia [p=0.001]. We suggest that if FSH is less than twice the normal, inhibin-B should be measured and if its level is less than 100 pg/mL, we can cancel about the half of unnecessary diagnostic testicular biopsies
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Testis
/
Biopsy
/
Cross-Sectional Studies
/
Azoospermia
/
Follicle Stimulating Hormone
/
Infertility, Male
Type of study:
Prevalence study
Limits:
Adolescent
/
Adult
/
Humans
/
Male
Language:
English
Journal:
Iran. J. Reprod. Med.
Year:
2012
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