Anti-proliferation effect of Hevea brasiliensis latex B-serum on human breast epithelial cells
Pakistan Journal of Pharmaceutical Sciences. 2012; 25 (3): 645-650
in English
| IMEMR
| ID: emr-144419
ABSTRACT
The rubber tree [Hevea brasiliensis] extracts are becoming increasingly visible in pharmaceutical and therapeutical research. The present study is aimed at examining the specific anti-proliferation property of H. brasiliensis latex B-serum sub-fractions against human breast cancer epithelial cell lines MCF-7 and MDA-MB231. The results showed that the latex whole B-serum and DBP sub-fraction exerted a specific anti-proliferation activity against cancer origin cells MDA-MB231 but had little effect on non-cancer-origin cells. On the other hand, the anti-proliferative activity was diminished in the pre-heated B-serum fractions. With the low toxicity that the B-serum demonstrated previously in Brine Shrimp Lethality Test [BSLT], the present results suggest the potential use of the B-serum subfractions in cancer treatment
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Artemia
/
Bread
/
Breast
/
Cell Line, Tumor
/
Cell Proliferation
/
Epithelial Cells
/
Latex
Limits:
Animals
/
Female
/
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Pak. J. Pharm. Sci.
Year:
2012
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