Serum concentration of vascular endothelial growth factor [VEGF] in non complicated type II diabetes mellitus and its relation to the degree of diabetic control

ABSTRACT

This study detremined the serum level of Vascular Endothelial Growth Factor VEGF in non-complicated type II diabetes mellitus and searched for a relationship between it and the degree of diabetic control. The serum level of VEGF was measured using an Enzyme ImmunoAssay in twenty eight patients with uncomplicated type II diabetes mellitus and in ten healthy non-diabetic subjects. The diabetic patients had serum level of VEGF significantly higher than these in controls [P < 0.001], and there was significantly positive correlation between serumlevels of VEGF and the degree of diabetic control particularly HbA1. In conclusion; the results of this study suggested that circulating VEGF is not specific for diabetic vascular complications and chronic hyperglycaemia may be one of the factors regulating VEGF induction and supposed that the elevated VEGF production under high glucose conditions may play role in the accelerated vascular disease observed in diabetes mellitus