Laminarin enhanced immunological disorders of septicimeric albino rats infected with aeromonas hydrophila

ABSTRACT

Aeromonas hydrophila is increasingly recognized as a pathogen of man that gives rise to both intestinal and extraintestinal infection. This study examined the effect of one the immunostimulants; fungal cell-wall beta-1, 3-D-glucan [Laminarin] on the immune response to Aeromonas hydrophila in albino rats. Intraperitoneal injection of 0.2 ml of 1% laminarin [15 mg/100 g b.wt] stimulated humoral immunity. On the ninth day, after application of laminarin in vivo, a statistically higher value of total Ig [p < 0.05] was observed. At the same time, serum total immunoglobulins [25.5 +/- 2] g/L in bacterial groups were significantly higher [p <0.05], compared to the control group [17 +/- 2] g/L. For Aeromonas infected group, all Ig classes showed increase statistically significant [p<0.05]. On the other hand laminarin groups exhibited reduced values of Ig subclasses but still higher than control values. This was reported for all time period. Rats were divided into 3 equal groups designated, Aeromonas infected, Laminarin-treated and control groups. Infection was carrid out by intraperitoneal injection of 2x10[6] bacteria daily for 6 days