Augmented hageman factor and prolactin titres in patients with acute myocardial infarction

ABSTRACT

High titres of prolactin and increased Hageman factor coagulant activity was observed in 18 patients with acute myocardial infarction. There is a direct correlation between plasma prolactin titre and coagulant activity of Hageman factor. These data support the evidence in animal models that prolactin can raise Hageman factor titre. Possibly by increasing hepatic protein synthesis. Whether an elevated coagulate activity of Hageman factor plays a role in the pathogenesis of thrombosis in myocardial infarction is uncertain