Amniotic fluid creatinine in normal and abnormal pregnancy

ABSTRACT

Creatinine, an important constituent of the amniotic fluid that was recently used in clinical obstetrics to assess the foetal maturity in uterois it was found to increase progressively as pregnancy advances. To study the effect of hypertensive toxaemia of pregnancy on the amniotic fluid creatinine, 135 pregnant patients in their last trimester were included in this work 35 cases of normal pregnancy and 100 cases of hypertensive toxaemia. All have had abdominal amniocentesis, and the creatinine content was estimated by the Coleman Junior spectrophotometer using the alkaline picrate method of Bonsnes and Tausky