Effect of insulin treatment on some metabolic changes on experimentally induced tumor in female mice

ABSTRACT

Insulin administration in TB-mice caused a very highly significant decrease in the values of plasma glucose, triacylglycerols, free fatty acids, total ketone bodies and urea concentrations. On the other hand, plasma albumin, total proteins and liver glycogen concentrations were markedly increased. Meanwhile, insulin administration in NTB-mice caused a significant decrease in the values of plasma glucose and free fatty acids concentrations. However, the mean values of plasma triacylglycerols and total ketone bodies levels showed a highly significant decrease after insulin administrations. On contrary, the value of plasma lactate, total proteins, albumin and liver glycogen concentrations were significantly increased. The results of this study indicated that, insulin treatment can reverse the experimental cancer cachexia, and it's anabolic therapy, has potential benefits in cancer treatment by shifting glucose metabolism toward the host and away from the tumor