Some biochemical alterations in serum and tissues of rats after administration of diazepam drug

ABSTRACT

Diazepam is a member of benzodiazepine derivatives used in veterinary medicine as a sedative, tranquilizer, behavioral modifier and anaesthesia induction agent and in human practices as muscle relaxant, anticonvulsant and hypnotic. This work was carried out to study the effect of diazepam on thyroid gland and some biochemical parameters in serum and tissues of albino rats. The study included 60 adult male albino rats which were classified into three equal groups. Each group subdivided into two equal subgroups of ten rats, each one represent the control and injected with saline and the other represent the test group and injected with diazepam [10 mg/kg] for one, two and three weeks for group I, II and III respectively. The obtained results showed significant increase in serum T[3] [group II and III], Glucose [second and third groups], urea [in third group only], creatinine [group II and III], ALT [alanine amino transferase] in all groups and in both total and direct bilirubin [group II and III]. While significant decreases were recorded in serum total proteins [in II and III groups], albumin and A/G ratio in all groups, in addition to vitamin C and glycogen in liver tissue [group II and III]