Study of fibrinopeptide A, fibrin monomer and fibrin degradation products in non-insulin dependent diabetes mellitus

ABSTRACT

The study was carried out on 20 non-insulin dependent diabetics and 10 healthy adult control subjects. The work aimed at estimation of fibrinopeptide A [FPA], fibrin monomer [FM] and fibrin degradation products [FDP] in non-insulin dependent diabetic patients with and without vascular complications, in addition to euglobulin clot lysis time [EGCLT], blood sugar, serum triglycerides, serum cholesterol, HDL-cholesterol and LDL-cholesterol. Serum fibrinopeptide-A [FPA] level was elevated in diabetics with vascular complications, reflecting augmented thrombin activity. EGCLT showed significant prolongation in diabetics with vascular complications. Pathological levels of FDP were detected in three diabetic patients [30%] with vascular complications. The significance of these findings were then analyzed and discussed