Early development of osteoporosis in male smokers with hypoandrogenism due to fascioliasis with or without schistosomiasis added by life style

ABSTRACT

The rnultifactor outcome of hypoandrogenemia with the impact of oxidative stress induced by glucose intolerance, fascioliasis with or without schistosomiasis and cumulative smoking influence on bone remodeling and the early development of osteo-porotic manifestations were studied. The effect on vascular endothelium immune mediated mechanisms and antioxidant capacity were monitored in cases of youth aged selected male smokers involving 20 with hypoandrogenemia who were either subjected to sedentary life style, glucose intolerance fascioliasis hepatic fibrosis [FHF] [G1] or without [G2] and GI after following 6 months therapy [G3]. Monitoring of clinical picture and biochemical assessments of osteoporotic indices [osteocolcin, bone alkaline phosphatase, parathyroid hormone, urinary cyclic AMP], hypoandrogenism [dehydroepiandrosterane sulphate or DHEAS and testosterone] glycemic determinant [insulin] immuno-inflammatory response [inter-leukein-6, tumor necrosis factor a, E-selectin, ceruloplasmin] smoking index [serum cotinine], total antioxidant capacity [AOC] and lipid peroxidation [malonedialdehyde] was done before and after 6 months therapeutic program involving supplement of DHEAS, mirazid, chromium picolinate, and megavit zinc alongside smoking cessation and physical exercise daily for at least 30 minutes. Treatment with Mirazid supplied as 10 mg/kg for 6 successive days resulted in 100% cure of fascioliasis whether single or combined with schistosomiasis