Serum leukotriene B4 level in children with active rheumatic arthritis

ABSTRACT

The possible association of leukotriene 84 [LTB4]-like activity with the development of active rheumatic arthritis was studied in 25 children with the disease and in 15 normal subjects. Serum LTB4like activity was found to be significantly higher in the active stage of the disease when compared with the values obtained during the inactive stage and from healthy children. No correlation was found between LTB4-activity and other laboratory parameters, e.g. hemoglobin level, white cell count and erythrocyte sedimentation rate