Comparative effect of petroselinum sativum extract and rutin on liver functions

ABSTRACT

Serum enzymes are very important in clinical diagnosis of diseases and estimation of liver damage of intoxicated rats by CCL[4]. In this study the effect of Petroselinum sativwn extracts was measured on the enzyme activities of liver transaminase "ALT, AST, ALP, and LDH". Also, the activity of lysosomal enzymes "ACP; beta-GAL, and beta-NAG In addition to superoxide dismutase as an antioxidant enzyme were determined after oral treatment with two concentrations "50 and 100 mg/kg b.w" for 21 days after injection i.p. of CCL[4] to evaluate the possible curative effect for the ethanolic extract of parsley. The activity of SOD as an antioxidant enzyme was also studied. Rutin as a standard antioxidant was orally administered as single dose "100 mg/kg b.w" for the same periods "10, and 20 days". This experiment was performed in two groups of rats "intoxicated and nontoxicated treatments". The results revealed that the liver enzymes activity "ALT, AST, ALP, and LDH" were markedly increased in hepatotoxic rats after the duration time. The higher activities of these enzymes could be referred to induced cell damage after CCL[4] treatment. Also, the lysosomal enzymes such as "ACP, beta-GAL, and beta-NAG" were markedly increased in parallel to the hepatoxic rats, SOD activity was significantly decreased. After plant extract administration by the two concentrations and Rutin by single dose, the enzyme activities of "ALT, AST, ALP, LDH, ACP, beta-GAL, and beta-NAG" were ameliorated and decreased significantly as compared to the control group. SOD activity was increased. Petroselinum sativum ethanolic extract exerted a curative effect on the enzyme activities of transaminase, "ALP, LDH, and the activities of lysosomal enzymes of rat liver. Also, this extract suppressed the oxidative stress by enhancement of the SOD activity