Antioxidant activity for a novel phenolic glycoside from koelreuteria elegans

ABSTRACT

Reactive oxygen species [ROS] have been implicated in the pathophysiology of many diseases such as atherosclerosis, Alzheimer's and Parkinson's diseases. Additional evidence also suggests ROS may play a role in the decline in neuronal function during normal aging. Phytochemical investigation of koelreuteria elegans resulted in isolation of a new benzoic acid monoglycoside, its structure was established as benzoic acid 4-0-alpha-L-arabinopyranoside [compound 1] which exhibited strong radical scavenging properties on lipid peroxidation, hydroxyl radical and superoxide anion generation. Three other known flavonol glycosides; quercetin-3-O-alpha-L-arabinopyranside [compound 2], kaempferol-3-O-alpha-L-arabinopyranoside [compound 3] and ombuin 3-O-alpha-L-rharnnopyranosyl-6-D-glucopyranosyl [compound 4], in addition to a triterpene saponin 3-O-beta-D-glucopyranosyl[1-2][alpha-L-rhamnopyranosyl[1-3]] beta-D-glucuronopyranosyl 28-0-angeloyl-camelliagenin A [comped 5] were also isolated