CD44V6 and K167 expression in nodal and disseminated

ABSTRACT

CD44 is a multifunctional cell surface adhesion molecule family, expressed in many cell types. High expression of the standard CD44s and its variant form CD44v6 has been reported to be associated with tumor dissemination in non Hodgkin 's lymphoma The aim of this study was to evaluate the expression of CD44v6 and Ki67 in disseminated and localized nodal B-cell lymphomas, and their relation to tumor histopathological grading and clinical staging. We examined 70 cases of B-cell NHL [36 disseminated, stages IlI IV and 34 nodal, stages I, H]for expression of CD44v6 and Ki67 immunohistochemically. We found that CD44v6 was expressed in [18/70 cases, 25.7%] of the studied group with 14 cases from the CD44v6 positive cases of the diffuse large B-cell lymphoma type, p<0. 005]. Ki67 was expressed in [58/70 cases, 82.8%] of the studied cases with [48 Ki67 positive cases] of the diffuse large B-cell lymphoma type, p<0.005]. We concluded that CD44v6 expression is associated with lymphoma cell dissemination, advanced clinical stage and high histological grading