LJM-Libyan Journal of Medicine. 2009; 4 (3): 97-103
in English
| IMEMR
| ID: emr-146588
ABSTRACT
Traumatic injury/hemorrhagic shock [T/HS] elicits an acute inflammatory response that may result in death. Inflammation describes a coordinated series of molecular, cellular, tissue, organ, and systemic responses that drive the pathology of various diseases including T/HS and traumatic brain injury [TBI]. Inflammation is a finely tuned, dynamic, highly-regulated process that is not inherently detrimental, but rather required for immune surveillance, optimal post-injury tissue repair, and regeneration. The inflammatory response is driven by cytokines and chemokines and is partially propagated by damaged tissue-derived products [Damage-associated Molecular Patterns; DAMP's]. DAMPs perpetuate inflammation through the release of pro-inflammatory cytokines, but may also inhibit anti-inflammatory cytokines. Various animal models of T/HS in mice, rats, pigs, dogs, and non-human primates have been utilized in an attempt to move from bench to bedside. Novel approaches, including those from the field of systems biology, may yield therapeutic breakthroughs in T/HS and TBI in the near future
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Shock, Hemorrhagic
/
Wounds and Injuries
/
Cytokines
/
Interleukin-6
/
Interleukin-10
/
Chemokines
/
Disease Models, Animal
/
Inflammation
Language:
English
Journal:
Libyan J. Med.
Year:
2009
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