Effect of drugs; baehavior of mice measured by modified hole board head-dipping exploratory test parameter

ABSTRACT

The aim of this study was to determine head-dipping exploratory test parameter as a measure of strong modulating effect on brain and behavior. It was an observational animal study. University of Karachi. Period Jan 2004 to July 2006. In this present study, drugs used reserpine, nux- vomica; anacardium and chlorpromazine were wide range of pharmacological actions. We evaluate the effectiveness of these drugs as agents with modulating effect on brain and behavior accessed by head dipping parameter. In this study, 25 mice were included belonging to both sexes. The study animals were divided into five groups of five animals each. Four groups were given drugs and one group was kept as control. Mice [20-35g] of either sex were used in this study. One group was kept as control for drugs. Mice were kept under room temperature. Tap-water was allowed ad-Lihitum.30 minutes after giving drugs, animals were observed for 10 minutes with two minutes of interval. Tablet crushed in 10ml of water, 1 cc was given. Screening method used was head dipping. Strychnos Nux-Vomica when used in a dose of 0.07mg has strong action on cholinergic system, CNS activity and frequent head dipping [39.8 +/- 28.8] was observed. Rauwolfia serpentine is an active alkaloid particularly present in reserpine [62.2 +/- 43.4] no significant head dipping effect was observed. Anacardium [37.2 +/- 28.6] and Chlorpromazine [39.4 +/- 32.4], show decrease effects. Keeping in view, the medicinal importance of these herbs, our present study was designed to screen these drugs for CNS activity on albino mice