[ effect of parenteral administration of erythromycin on Immunoglobulin G absorption in neonatal calves]

ABSTRACT

Motilides mainly erythromycin have a great ability to increase abomasal emptying rate. The aim of this study was to evaluate the effect of erythromycin as a prokinetic agent on abomasal emptying rate and Immunoglobulin G absorption in neonatal calves. Twelve holstein neonate calves were divided into two groups [treatment and control] of 6 Calves each. One hour after birth, treatment and control groups were injected by erythromycine [8.8 mg/kg; IM] and normal saline [IM]. After 30 minutes, calves were fed by 3 liters of colostrum using esophageal tube. Venous blood samples for determination of plasma IgG were obtained at 1, 3, 6, 9, 12, 18, 24, 36, 48 hours and 5 and 7 days after birth. The results showed that administration of erythromycin caused a significant increase in the serum IgG level [20.394 mg/mL], compared to the control group [15.021 mg/mL]. This study revealed that erythromycin increases the serum IgG level probably through abomasal emptying acceleration