Comparison of gastric ulcerogenicity of percolated extract of Anacardium occidentale [Cashew Nut] with indomethacin in rats

ABSTRACT

In traditional Iranian medicine, the core of the fruit of Anacardium occidentale [cashew nut] has been used in the management of the pain. In this study gastric ulcerogenicity effect of the percolated extract of A. occidentale was investigated in rats. The extract or indomethacin [200, 300, 400 and 800 mg/kg] was administrated orally. In the control group normal saline [5 ml/kg] was used. After getting extract, indomethacin or normal saline, animals were slaughtered. The stomachs were detached and 10 ml of 2% formalin injected in to the stomach for fixing the internal coat of the gastric wall. The stomachs were then slitted open near the bigger curvature and lacerations in the glandular part were evaluated. The ulcer index was determined using j-score. Data demonstrated that the oral dose of 200 mg/kg of the extract did not provoke any ulcerogenic consequence in the rat's stomach. Gastric ulcerginicity of the extract at the doses of 300, 400 and 800 mg/kg was less than the similar doses of indomethacin [p<0.01]. Therefore, A. occidentale is an appropriate plant for ongoing search for establishing an analgesic agent with low gastrointestinal side effects for clinical use