Role of electrolytes disturbances and Na[+]-K[+]-ATPase in cisplatin-induced renal toxicity and effects of ethanolic extract of Cichorium intybus

ABSTRACT

Cisplatin is known by its toxicity by disturbing electrolytes homeostasis. Thus we aimed to find out the role of herbal plant Cichorium intybus on Cisplatin - induced toxicity. 24 male Albino Wistar rats were randomly divided into 4 groups Group I is termed as untreated control; Group II is Cisplatin control and received 3 mg/kg b.w.; i.p.; Group III received C. intybus ethanolic extract at a dose of 500 mg/kg b.w. orally for 10 consecutive days and Group IV is Cisplatin + C. intybus pretreated group. C. intybus is given 30 minutes prior to Cisplatin. Cisplatin-induced electrolytes disturbances is indicated by increase Intra-erythrocyte sodium content, decreased plasma magnesium, calcium and Intra-erythrocyte Na[+]-K[+]-ATPase which implicates the renal toxicity. At a dose of 500 mg/kg b.w. of C. Intybus pretreatment showed partial counter action on the electrolytes imbalances and Na[+]-K[+]-ATPase activity