[Effect of supplementation with grape seed extract [vitis vinifera] on serum lipid profiles in patient with type 2 diabetes]

ABSTRACT

Lipid abnormalities are a major cause of cardiovascular diseases in patients with type 2 diabetes. The present study was therefore designed to investigate the supplemental effects of grape seed extract on serum lipid profiles of patients with type 2 diabetes. The study was a randomized, triple-blind, clinical trial in which 48 patients with type 2 diabetes were randomly assigned to 2 groups, the grape seed extract supplement and the placebo group. The patients in the grape seed extract group received 200 mg/d grape seed extract for 8 weeks while the placebo group received a corresponding placebo. At baseline and or the end of the 8[th] week of the study, 5 ml blood was collected after a 12 to 14-hour fast from each patient and serum triglycerides, total cholesterol, HDL-C, and LDL-C were measured. There were no significant differences between the two groups with regard to mean changes of serum triglycerides, total cholesterol, HDL-C, and LDL-C. The results of the present study indicate that grape seed extract supplement has no effect on serum lipid profiles in patients with type 2 diabetes