Bilateral proliferative retinopathy as the initial presentation of chronic myeloid leukemia

ABSTRACT

The authors report a rare case of a 48-year-old male with chronic myeloid leukemia [CML] who initially presented with a bilateral proliferative retinopathy. The patient complained of recent visual loss and floaters in both eyes [BE]. Ophthalmologic evaluation revealed a best corrected visual acuity [BCVA] of 20/50 in the right eye and 20/200 in the left eye [LE]. Fundoscopy showed the presence of bilateral peripheral capillary dropout with multiple retinal sea fan neovascularisations, which were confirmed on fluorescein angiography. Full blood count revealed hyperleukocytosis, thrombocytosis, anemia, and hyperuricemia. Bone marrow aspiration and biopsy showed the reciprocal chromosomal translocation t [9;22], diagnostic of CML. The patient was started on hydroxyurea, allopurinol and imatinib mesylate. He received bilateral panretinal laser photocoagulation and a vitrectomy was performed in the LE. The patient has been in complete hematologic, cytogenetic, and major molecular remission while on imatinib and his BCVA is 20/25 in BE