Fetal and neonatal outcomes of the magnesium sulfate and nefidipine in suppression of preterm labor

ABSTRACT

Preterm Labor occurs in 11.8% of all pregnancies and is the most etiology of Neonatal morbidity without Anomalies and after intra-partum congenital Anomalies is the second etiology of Neonatal mortality that has high economic and psychiatric cost. Premature infants have Neurotic complications and they are week about physical growth, practical cognitive and lesson tasks. One of usage drugs in prevention of preterm labor is Nefidipin. This research is a Double blind RCT. All of pregnant mothers with 26-34 weeks with signs of preterm labor have come to Alzahra and Talegani hospitals were research population. Research samples were 80 pregnant women that have eligibility criteria and treated with Sulphate mg and Nefidipin. Samples allocated randomly in 2 groups by use of rand list software and block of 3 and 6. In group A were used Sulphate mg 4 g first and then 2g/h for 48 h and group B were used Nefidipin 20 mg first and 20 mg /half h after. Success of treatment was measured by Partograph and checklist. Data was analyzed by statistic tests and spss ver. 13. Neonatal complications such as 1 min Apgar and 5 min Apgar score, Sao2 and ABG in 2 groups, that treatment could not prevent contractions, have not significantly different. But there were significant different about Fetal complications such as bit to bit variation, decrease of fetal movement and dropt of base line of FHR [p uterus contractions and improve of feto-Neonatal outcomes that these will prevent further Growth and Development complications in Neonatal and this drug can be best supplement for Sulphate mg in suppress of preterm contractions of uterus