Her2/neu expression in Wilms' tumor and correlation with histopathologic findings
Iranian Journal of Cancer Prevention. 2013; 6 (3): 160-164
in English
| IMEMR
| ID: emr-148696
ABSTRACT
Wilms' tumor is an emberyonal tumor arising from remnants of immature renal tissue. Her2/neu is an onco-protein which mediates cellular proliferation, differentiation and survival. In the current study, we analyzed Her2/neu expression in 40 Wilms' tumors. The clinico-demographic data of 40 patients with Wilms' tumor were retrieved. Immunohistochemical staining for HER2/neu was performed. Her2/neuimmunoreactivity was evaluated by Canadian Consensus 2007 scoring system. Among the 38 specimens with epithelial component, 68.5% were positive for Her2/neu, whereas there was immunoreactivity in 37% of 38 blastemal, and 12% of 31 stromal components. The Her2/neu expression was significantly higher in early stages [81.5%] than in advanced stages [36.4%] in epithelial component, but not in other components. This study suggested that Her2/neuexpression is associated with epithelial cell differentiation accompanied by lower stages of tumor. No significant relationship was found between Her2/neu positivity and tumor size and patient's age and gender
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Peptide Fragments
/
Receptor, ErbB-2
/
Kidney Neoplasms
/
Antigens, Neoplasm
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Iran. J. Cancer Prevention
Year:
2013
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