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Epigallocatechin-3-gallate [EGCG] inhibits 3-hydroxy-3-methylglutaryl-CoA reductase in the presence of glycerol
Pakistan Journal of Pharmaceutical Sciences. 2014; 27 (6): 1905-1910
in English | IMEMR | ID: emr-148836
Responsible library: EMRO
ABSTRACT
The inhibition of 3-hydroxy-3-methylglutaryl CoA reductase [HMGCR] is considered able to decrease serum cholesterol levels and dramatically reduce the risk for cardiovascular and cerebrovascular diseases. The statins, competitive inhibitors of HMGCR, have been employed to control hypercholesterolemia. But their side effects, especially their safety of long-term administration have attracted great attention. Therefore, there is still an urgent requirement for the development of safer inhibitors of HMGCR with less serious side effects. In this study, we cloned and purified the catalytic domain of human HMGCR [delta HMGCR], and applied the method of Ultra Performance Liquid Chromatography [UPLC] to assay delta HMGCR activity and screen its inhibitors from natural products. The results indicated that EGCG can inhibit delta HMGCR in the presence of some glycerol in vitro and can decrease cellular total cholesterol in HepG2 cells. As a consequence, it is promising to put EGCG into the development of hypolipidemic health product
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Index: IMEMR (Eastern Mediterranean) Main subject: Chromatography, High Pressure Liquid / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Glycerol / Hydroxymethylglutaryl CoA Reductases Language: English Journal: Pak. J. Pharm. Sci. Year: 2014

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Index: IMEMR (Eastern Mediterranean) Main subject: Chromatography, High Pressure Liquid / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Glycerol / Hydroxymethylglutaryl CoA Reductases Language: English Journal: Pak. J. Pharm. Sci. Year: 2014