Comparison of ranson criteria with paraoxonase, oxidative stress index and CRP in patients with acute pancreatitis

ABSTRACT

We aimed to compare paraoxonase levels, total antioxidant levels, total oxidant levels, oxidative stress index between Ranson score and C-reactive protein levels in acute pancreatitis. Thirty two patients were included in the study. Their Ranson scores were recorded upon arrival at the hospital and at the 48th hour. During the recovery period [6th week], CRP, paraoxonase and oxidative stress index levels were simultaneously checked. Mean first ranson score of patients were 1.4 +/- 1.4, mean paraoxonase levels of patients paraoksonaz were 176.5 +/- 108, and mean CRP levels of patients were 49 +/- 51. When the paraoxonase levels of the patients with systemic diseases and patients without systemic diseases were compared, no difference was detected in the arrival levels of paraoxonase, while differences were observed in paraoxonase-II [182.3 +/- 38.5, 192 +/- 28.2] and paraoxonase-III [158 +/- 28.7, 230.9 +/- 33.1] levels. However, this was not statistically significant. A positive correlation was observed among patients CRP, paraoxonase levels and oxidative stress index and Ranson criteria. Paraoxonase and oxidative stress index can be used as new parameters for predicting clinical outcome of acute pancreatitis.