[Evaluation of the diagnostic value of the first and third trimester maternal mean platelet volume [MPV] for prediction of pre-eclampsia]

ABSTRACT

Preeclampsia is a severe complication of pregnancy, often associated with significant morbidity and mortality for both mother and newborn. The aim of this study is to evaluate if mean platelet volume during first trimester predict preeclampsia or preterm labour development. All pregnant women, in the first trimester, attending to prenatal clinic at Shahid Akbar Abadi Hospital for routine obstetric care during 2010 were enrolled. According to the study, blood sample was taken from women at the first visit in first trimesters and the third and recorded. After delivery, outcome data were obtained. A total of 400 women were included and 35 [8.8%] and 96 [24%] of them developed preeclampsia and preterm labor, respectively. Parameters of platelet during pregnancy were similar between groups. MPV values of pre-eclamptic women were not significantly different with normotensive counterparts. Our study did not provide evidence that MPV changes could predict preeclampsia or preterm labor development.