application of theta burst stimulation in negative symptoms of patients with Schizophrenia

ABSTRACT

The aim of this research is study of theta burst stimulation on left dorsolateral prefrontal cortex in remission of negative symptoms in patients with schizophrenia. In a placebo, double blind and randomized study, 10 patients with schizophrenia assigned in experimental and control group. The experimental group received 20 sessions of TBS with 50 Hz frequency, but control group were treated just with sham coil. All the patients were appraised before, the 10th sessions and after the treatment. The treatment efficacy was calculated with ANOVA. The results indicated that the experimental group had statistical difference to control group in negative symptoms [p>0.007] and social functioning [p>0.01]. But there weren't any significant difference in quality of life and depression between two groups. Theta burst stimulation can be mentioned as an efficacious treatment for people with schizophrenia.