Egyptian Journal of Cardiothoracic Anesthesia. 2010; 4 (1): 35-43
in English
| IMEMR
| ID: emr-150594
ABSTRACT
Pulmonary artery hypertension is a disorder with limited treatment options and poor prognosis. We studied the effect of tadalafil, a selective phosphodiesterase type 5 inhibitor, in patients with this disease. In fifty patients subjected to mitral valve surgery [26 males, 24 females] aged 19040 years, with pulmonary artery hypertension, 10 mg tadalafil single dose was given to 25 patients after induction of anesthesia, and its effect was compared to a placebo given to the other 25 patients, all fifty patients had a comprehensive Transoesophageal echo examination including tissue Doppler and Tie index. Tadalafil resulted in a marked improvement in right ventricular function as regards tissue Doppler and Tie index [0.3110.05] compared to [0.34 +/- 0.02] in control group [p value =0.01] and pulmonary artery pressure [52.6 +/- 12.17] compared to control group [59.60 +/- 11.31] [p value =0.04]. 10 mg Single dose tadalafil was well tolerated and had a beneficial effect in patients with pulmonary artery hypertension undergoing mitral valve surgery
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Carbolines
/
Ventricular Function, Right
/
Treatment Outcome
/
Mitral Valve
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Egypt. J. Cardiothorac. Anesth.
Year:
2010
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