Biochemical, histological and histochemical studies of oat [Avena sativa] on hyperlipidemic rats

ABSTRACT

Hyperlipidemia is an elevation of lipids in the blood stream and these lipids include fats, fatty acids, cholesterol, cholesterol esters, phospholipids, and triglycerides. Hyperlipidemia is associated with hepatic fat accumulation. Six groups [5rat/group] of female albino [Rattus albinus] were used. The 1[st] group used as control, in the 2[nd] group Hyperlipidemia [25% fat and 2% cholesterol] was induced for 3 weeks only then sacrified, the 3[rd] group was hyperlipidemic rats for 3 weeks then left other 3 weeks without any additional treatment as a recovery period, the 4[th] group served as hyperlipidemic group for 3 weeks then treated with Avena sativa for another 3 weeks [200 g/Kg diet], the 5[th] group was hyperlipidemic [25% fat and 2% cholesterol] for 6 weeks and the 6[th] group served as hyperlipidemic rats for 6 weeks, and at the same time given Avena sativa in diet [200 g/Kg diet]. The biochemical parameters showed highly significant increase in body weight, serum glucose, AST, ALT, GGT, LDH, urea, creatinine, total protein, albumin, total lipids, cholesterol, triglycerides and LDL-cholesterol, while there was highly significant decrease in HDL- cholesterol.Many histopathological and histochemical changes were detected in liver tissue of the hyperlipidemic rats. Meanwhile, the treatment with oat ameliorated the biochemical parameters, histological and histochemical results. It is recommend to use oat in diets for hyperlipidemic patients or those people who have hyperlipidemic family history