Effect of crowding stress and /or sulpiride treatment on some physiological and histological parameters in female albino rats

ABSTRACT

Crowding is the most stressful factor on human being. So these studies aimed to clarify effect on some physiological and histological parameters. 36 Female rats were divided into four groups [6/each]1-control, 2-treated with sulpiride drug,3- crowded exposure 4- crowded + drug. drug recorded a significant increase only in the percentage of body weight gain but the other parameters showed no significant changes. Stress recorded a significant increase in glucose, ALT, GGT, TP, globulin, creatinine, total lipids, TG, cholesterol, HDL-C, LDL-C. A significant decrease in percentage of body weight gain and A/G ratio were also detected. Sulpiride drug ameliorated most of these parameters. Concerning the histological and histochemical studies sulpiride treatment showed no detectable changes in the kidney and liver tissues with exception of increased lymphocytes. Exposure to crowding showed many dystrophic changes in both tissue, but drug treatment improved all the previous changes and this indicates the protective effect of sulpiride against crowding exposure. it is useful to use sulpiride drug in people who exposed to crowded stress