Effects of orally fed diazinon on some biochemical parameters of male albino rats

ABSTRACT

The current investigation was carried out to study the effect of orally administration of diazinon insecticide on some biochemical blood indices on male albino rats. The organophosphorus insecticide, diazinon was orally administrated at a dose [100mg/kg body weight=1/3LD50], daily for 10 days [short -term] and 20 days [long -term] to adult male albino rats. The results revealed the following 1- Diazinon led to an increase in rat blood serum glucose and T3 [short and long -term]; AST,ALT,and T4 [long-term].2- Diazinon reduced the serum content of total cholesterol and protein in short-term treated rats. 3- Treatment of rats with diazinon did not alter activity of AST, ALT and T4 level at short -term period .In addition ; ALP serum levels were not altered in both short and long -term treated rats