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Therapeutic effect of lauric acid, a medium chain saturated fatty acid on giardia lamblia in experimentally infected hamsters
PUJ-Parasitologists United Journal. 2013; 6 (1): 89-98
in English | IMEMR | ID: emr-150935
ABSTRACT
Giardia lamblia is a common cause of diarrheal disease in humans, particularly among children causing nutritional disorders. Metronidazole and other nitroimidazoles are commonly used as the mainstay of therapy for giardiasis. The present work was carried out to evaluate the effect of lauric acid, a natural product extracted from coconut oil, against G. lamblia in experimentally infected hamsters [Mesocricetus auratus]. Sixty five laboratory bred hamsters were used in the current experimental study. Ten served as normal non infected non treated control group [A]. Fifteen uninfected hamsters served as drug control group [B] five received metronidazole group [B1]; five received lauric acid group [B2] and five received combined treatment [metronidazole and lauric acid] at a half doses of each drug [B3]. The remaining forty hamsters were orally infected by 10,000 G. lamblia cysts/hamster [group C], and were divided into 4 groups of 10 hamsters each infected control [C1]; metronidazole treated [C2]; lauric acid treated [C3]; combined treatment at a half dose of each drug [C4]. Two weeks after treatment, compared with infected non treated controls, the highest percentages of reduction in the number of Giardia cysts and trophozoites were in the group that received combined treatment [98.83%, 96.95%, respectively]. Lower percentages of reduction were recorded for the metronidazole treated group [93.77%, 95.50%, respectively] and the lauric acid treated group [82.03%, 78.76%, respectively]. Histopathological examination and electron microscopic examination revealed complete healing of intestinal mucosa after the combined treatment, while partial healing of the lining epithelium of the intestine was noticed after metronidazole or lauric acid treatment alone. Lauric acid improved the therapeutic effect against giardiasis when combined with metronidazole
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Index: IMEMR (Eastern Mediterranean) Main subject: Microscopy, Electron / Cricetinae / Animal Experimentation / Drug Combinations / Intestines / Lauric Acids / Metronidazole Limits: Animals Language: English Journal: Parasitologists United J. Year: 2013

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Index: IMEMR (Eastern Mediterranean) Main subject: Microscopy, Electron / Cricetinae / Animal Experimentation / Drug Combinations / Intestines / Lauric Acids / Metronidazole Limits: Animals Language: English Journal: Parasitologists United J. Year: 2013