Pattern of urinary albumin excretion in non-diabetic first-degree relatives of type 2 Diabetes Mellitus patients

ABSTRACT

To determine the pattern of urinary albumin excretion among non-diabetic first-degree relatives of patients with Type 2 DM residing in United Arab Emirates and to relate it to the socio-demographic profile and family history of chronic diseases. non-diabetic first-degree relatives of patients with Type 2 DM attending the Gulf Medical College Hospital [GMCH] or employed in the GMU/ GMCH were invited to participate in the study. None of the participants had any known renal disorder. Data was collected using a pilot-tested, interviewer-administered questionnaire. Albumin/Creatinine ratio [ACR] was measured in urine. Data was analyzed using PASW 19.0 software. Among the 231 participatns, 66.3% were male. 53.7% of the participants were in the 26-35 year age group. Forty [17.3%] had ACR higher than 10mg/g, of whom 10 had > 30mg/g. ACR was >15mg/ g in 9.9% of males and 18% of females. An increasing trend was seen with age. The percentage of participants having ACR 15-30 mg/ g was 6.2, 8.1, 11.4, 27.3 in age groups respectively. Among those with ACR > 10 mg/g, two reported a family history of kidney disorder, three stroke and seven CVD. Among the non-diabetic first-degree relatives of Type 2 DM patients, urinary albumin excretion level was higher among females and in the older age group