Pterygium excision and limbal conjunctival autograft with versus without the use of mitomycin-c in patients below the age of 45 years

ABSTRACT

To compare pterygium recurrence following excision with limbal conjuctival autograft with application of Mitomycin-C versus non application of Mitomycin-C in patients below age 45 years. Randomized Control Trial. This study was conducted at the Department of Ophthalmology, NMC, Multan from 15.06.2009 to 15.12.2009. Total 86 patients with the age range 25-44 years were selected for this study and categorized randomly into two groups. Group-I [n=43] and group-II [n=43]. Pterygium surgery was performed with limbal conjunctival autograft without the use of Mitomycin-C in group-I and with the use of Mitomycin-C in group-II. Three patients out of 86 cases did not visit for follow -up. Pterygium was more prevalent in males [n=65, 75.58%] and majority of the patients [n=36, 41.9%] were between 41-44 years of age. There were 7 [17.07%] cases of recurrence observed in group-I and only 1 [2.38%] case of recurrence in group-II, the difference in recurrence rate was statistically significant [p=0.02]. For pterygium surgery, limbal conjunctival autograft combined with intraoperative application of Mitomycin C is recommended