[Alterations in lipidic metabolism in hemodialysis patients]

ABSTRACT

Chronic kidney failure is associated with dyslipidemia and accelerated atherosclerosis. To study lipidic metabolism alterations in patients with chronic kidney failure on hemodialysis. The study interested 45 hemodialysis patients with a mean age of 49.04 +/- 15.92 years old and 45 healthy controls. A blood sample was collected from each patient and control to measure total cholesterol, triglycerides, HDL- cholesterol, LDL-cholesterol, apolipoproteins AI and B100, lipoprotein [a] and C Reactive Protein. A significant increase of serum triglycerides [p= 0.002], lipoprotein [a] [p = 0.001] and C Reactive Protein [p = 0.008] was observed in patients when compared with healthy controls. A significant decrease of serum total cholesterol [p=0.01], HDLcholesterol [p<0.001], LDL-cholesterol [p=0.005] and apolipoprotein AI [p<0.001] was also observed in patients. Disorders of lipidic metabolism are frequent in hemodialysis patients. These alterations can lead to cardiovascular disease in uremic patients