Effect of chlorpromazine and metoclopramide on the secretion of some hormones and central neurohumors in rat

ABSTRACT

After 3 weeks of daily intraperitoneal [i.p.] administration of cholorpromazine [10 mg/kg] or metoclopramide [0.15 mg/kg] to male rats, the whole brain levels of norepinephrine and dopamine significantly decreased. Serum prolactin, thyroxine and tri-iodothyronine levels significantly increased as compared to control values. Serotonin and ACTH were affected by chlorpromazine only. Brain histamine level did not change in both groups. It was concluded that drugs which after central dopaminergic mechanisms may exert significant influences on the secretion of some adenohypophyseal hormones. Serotonin may partially counteract the effect of dopamine. Brain histamine is unlikely to contribute in an important way to the major action of chlorpromazine and metoclopramide in the secretion of hormones